Product Description

HLA-DQA1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA25968-50, RA25968-100

Citations, Manuals and MSDS Available upon request.

Background: major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1) Homo sapiens HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages) . The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marro

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: IHC-p 1:50-200, ELISA 1:10000-20000

Alternative Names: HLA class II histocompatibility antigen, DQ alpha 1 chain (DC-1 alpha chain;DC-alpha;HLA-DCA;MHC class II DQA1)

Applications: IHC-p; IF (paraffin section) ; ELISA

Species Cross-Reactivity: Human

GeneID (Human): 100509457

SWISS: P01909

Source: Rabbit

Research Use Only