HLA-DQA1 rabbit pAb - ES8761

HLA-DQA1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8761-50, ES8761-100

Citations, Manuals and MSDS Available upon request.

Background: HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marro

Alternate Name: HLA class II histocompatibility antigen, DQ alpha 1 chain (DC-1 alpha chain; DC-alpha; HLA-DCA; MHC class II DQA1)

Source: Rabbit

Applications: IHC; IF; ELISA

Dilution: IHC-p 1:50-200, ELISA 1:10000-20000

Reactivity: Human

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human HLA-DQA1. AA range:21-70

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 100509457

Human SWISS Prot NO: P01909

Subcellular Location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

Research Use Only