Product Description

HLA-DQB1/2 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA25969-50, RA25969-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1) Homo sapiens HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marro

Reactivity: Human

Host: Rabbit

Applications: WB, IHC-p, IF (paraffin section), ELISA

Alternate Names: HLA-DQB1, HLA-DQB, HLA class II histocompatibility antigen, DQ beta 1 chain, MHC class II antigen DQB1, HLA-DQB2, HLA-DXB, HLA class II histocompatibility antigen, DQ beta 2 chainHLA class II histocompatibility antigen, DX beta chain, MHC class II antigen DQB2

Clonality: Polyclonal

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

Molecular Weight: 30

Protein Molecular Weight (kDa): 30

Storage: -20°C/1 year

Human Gene ID: 100507714

Human SwissProt Number: P01920/P05538

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only