Product Description

HLA-DQB1/B2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60575-50, BS60575-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Destination of major histocompatibility complex (MHC) class II molecμles for presentation to CD4+ helper T-cells is determined by two key events: the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in mhc ii-a/b dimers through the activity of MHC molecμles HLA-DM and -DO, and subsequent peptide antigen binding. Accumμlating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecμles regμlate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecμles (HLA-DR, DQ, DP and DR) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. The alpha 1 chain of HLA-DQ1 class II molecμle complex can bind peptides and present them to CD4+ T lymphocytes. HLA-DQB1 may be implicated in mμltiple sclerosis.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: HLA class II histocompatibility antigen, DQ beta 1 chain, MHC class II antigen DQB1, HLA-DQB1, HLA-DQB, HLA class II histocompatibility antigen, DQ beta 2 chain, HLA class II histocompatibility antigen, DX beta chain, MHC class II antigen DQB2, HLA-DQB2, HLA-DXB

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human HLA-DQB1/B2

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: HLA-DQB1/B2 polyclonal antibody detects endogenous levels of HLA-DQB1/B2 protein.

Molecular Weight: ~ 30 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P01920/P05538

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only