Product Description

HLA-G Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66909-50, MB66909-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: HLA-G is a non-classical MHC molecμle expressed by trophoblasts in placenta, thymic epithelial cells, and some tumors.Alternative splicing leads to generation of at least six isoforms, four that are transmembrane proteins and two that are soluble. It is an inhibitory molecμle involved in immune tolerance and escape, originally studied for its role in maternal tolerance of the fetus during pregnancy. HLA-G binds ILT2, ILT4, and KIR2DL4, playing a role in the regμlation of natural killer, T, and monocyte/macrophage cells . Its involvement in evasion of immune response makes it a potential target for immunotherapy.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: HLA-6.0, HLAG, HLA class I histocompatibility antigen, alpha chain G, HLA G antigen, MHC class I antigen G

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human HLA-G. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of HLA-G protein.

Molecular Weight: ~ 43 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P17693

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only