Product Description

HMGCR Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS65515-50, BS65515-100

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Swiss-Prot: P04035

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

Background: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Purification and Purity: affinity purified by Protein A

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: HMGCR monoclonal Antibody detects endogenous levels of HMGCR protein.

Bioworld Molecular Weight: ~97kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Anti-HMGCR at 1/1000 dilution

Alternative Name: 3 hydroxy 3 methylglutaryl CoA reductase; 3 hydroxy 3 methylglutaryl Coenzyme A reductase; 3 hydroxymethylglutaryl CoA reductase; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 3H3M; HMDH_HUMAN; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; Hydroxymethylglutaryl CoA reductase; LDLCQ3; MGC103269.

Immunogen: KLH conjugated synthetic peptide derived from human HMGCR:

Conjugate: Unconjugated

Modification: Unmodified