Product Description

HMGCR Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90652-50, BS90652-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P04035(Human) Q01237(Mouse) P51639(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB IP

All Applications: WB:1:1,000-1:2,000

Background: The human enzyme hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) limits the rate of cholesterol synthesis, a necessary process for cellular growth, in liver tissue. Phosphorylation of HMGCR inactivates the enzyme, which occurs via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from the product of the reductase reaction. Inhibitors of HMGCR (statins) exert anti-inflammatory effects and decrease the frequency of cardiovascular events by lowering plasma cholesterol. Additionally, intermediate products along the pathway catalyzed by HMGCR, which modulate signal transducing proteins such as Ras, provide possible ties between HMGCR regulation and new chemotherapeutic methods.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of HMGCR on Hela cellsLysates using anti-HMGCR antibody at 1/1,000 dilution.

Bioworld Molecular Weight: 97 kDa

Specificity: HMGCR polyclonal antibody detects endogenous levels of HMGCR protein.

Alternative Name: HMG-CoA reductase, HMGCR, 3 hydroxy 3 methylglutaryl CoA reductase, 3 hydroxy 3 methylglutaryl Coenzyme A reductase, 3 hydroxymethylglutaryl CoA reductase, 3-hydroxy-3-methylglutaryl CoA reductase (NADPH), 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3H3M, HMDH, HMG CoA reductase, HMG CoAR, HMG-CoA reductase, Hmgcr, Hydroxymethylglutaryl CoA reductase, LDLCQ3, MGC103269, Red,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified