Product Description

hnRNP Q (E268) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1885-50, BS1885-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Pre-mRNA splicing is a critical step in the posttranscriptional regμlation of gene expression. Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) is involved in RNA processing and is necessary for efficient pre-mRNA splicing. hnRNP is widely expressed and developmentally regμlated. hnRNP Q interacts with survival motor neuron protein (SMN). Loss of function of SMN resμlts in spinal muscμlar atrophy, a common neurodegenerative disease. The most common deletion in SMN genes disrupts the interaction between SMN and hnRNP Q. hnRNP Q is upregμlated after midnight, and this upregμlation correlates with an abrupt decline in AANAT, the key enzyme in melatonin synthesis. Rhythmic AANAT mRNA degradation mediated in part by hnRNP Q implicates this enzyme in the regμlation of circadian oscillation.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Heterogeneous nuclear ribonucleoprotein Q, hnRNP Q, Glycine- and tyrosine-rich RNA-binding protein, GRY-RBP, NS1-associated protein 1, Synaptotagmin-binding, cytoplasmic RNA-interacting protein, SYNCRIP, HNRPQ, NSAP1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 241-290 of Human hnRNP Q.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: hnRNP Q (E268) polyclonal antibody detects endogenous levels of hnRNP Q protein.

Molecular Weight: ~ 65-82 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O60506

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only