Product Description

hnRNP Q Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90657-50, BS90657-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O60506(Human) Q7TP47(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC IF, IHC

All Applications: WB:1:500-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200

Background: Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) is involved in RNA processing and is necessary for efficient pre-mRNA splicing. hnRNP is widely expressed and developmentally regulated. hnRNP Q interacts with survival motor neuron protein (SMN). Loss of function of SMN results in spinal muscular atrophy, a common neurodegenerative disease. The most common deletion in SMN genes disrupts the interaction between SMN and hnRNP Q. hnRNP Q is upregulated after midnight, and this upregulation correlates with an abrupt decline in AANAT, the key enzyme in melatonin synthesis. Rhythmic AANAT mRNA degradation mediated in part by hnRNP Q implicates this enzyme in the regulation of circadian oscillation.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: hnRNP Q polyclonal antibody detects endogenous levels of hnRNP Q protein.

Bioworld Molecular Weight: 70 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of hnRNP Q on K562 cell lysate using anti-hnRNP Q antibody at 1/1,000 dilution., ICC staining hnRNP Q in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: hnRNP Q, GRY-RBP, SYNCRIP, HNRPQ, NSAP1, cytoplasmic RNA-interacting protein, dJ3J17.2, Glycine and tyrosine rich RNA binding protein, Glycine- and tyrosine-rich RNA-binding protein, GRY RBP, GRY-RBP, GRYRBP, Heterogeneous nuclear ribonucleoprotein Q, hnRNP Q, HNRPQ, HNRPQ, HNRPQ1, NS1 associated protein 1, NS1-associated protein 1, NSAP1, pp68, RP1 3J17.2, Synaptotagmin binding cytoplasmic RNA interacting protein, Synaptotagmin-binding, Syncrip,

Immunogen: Recombinant protein to C-terminal human hnRNP Q.

Conjugate: Unconjugated

Modification: Unmodified