Product Description

Homer1 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11053-50, MB11053-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q86YM7

Host: Rabbit

Reactivity: Mouse, Rat

Applications: WB, IP,

All Applications: WB: 1/500-1/1000 IP: 1/20

Background: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines .

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 40 kDa; Observed MW: 46 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Homer1 in mouse brain lysates using Homer1 antibody., Western blot analysis of Homer1 in rat Brain lysates using Homer1 antibody.

Alternative Name: HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C

Immunogen: Recombinant protein of human Homer1

Conjugate: Unconjugated

Modification: Unmodified