HOX-B7 Polyclonal Antibody
Catalogue Numbers: BS60431-50, BS60431-100
Sizes: 50µl, 100µl
Alternative Name: Homeobox protein Hox-B7; Homeobox protein HHO.C1; Homeobox protein Hox-2C; HOXB7; HOX2C
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P09629
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
All Applications: WB: 1:500~1:1000
Background: The Hox proteins play a role in development and cellular differentiation by regulating downstream target genes. Specifically, the Hox proteins direct DNA-protein and protein-protein interactions that assist in determining the morphologic features associated with the anterior-posterior body axis. The mammalian HOX gene complex consists of 39 genes that are located on four linkage groups, which are dispersed over four chromosomes. A segment of the HoxB7 proximal promoter drives renal expression of reporter genes specifically in the ureteric bud and collecting ducts. Expression levels of HoxB7 are lower in lymph node metastasis-positive cancer tissues than negative cancer tissues. These results suggest that aberrant expression of HOX genes is related to the development of breast cancer and malignant behavior of cancer cells.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: HOX-B7 polyclonal antibody detects endogenous levels of HOX-B7 protein.
Bioworld Molecular Weight: ~ 25 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of HOX-B7 polyclonal antibody at 1:500 dilution
Lane 1: Hela cell lysate
Lane 2: Raw264.7 cell lysate
Lane 3: H9C2 cell lysate
Immunogen: A synthetic peptide corresponding to residues in Human HOX-B7.
Conjugate: Unconjugated
Modification: Unmodified