HP-1Alpha mouse Monoclonal Antibody (5E3) - BT-MCA0050

HP-1Alpha mouse Monoclonal Antibody (5E3)

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-MCA0050-20, BT-MCA0050-50, BT-MCA0050-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Research Areas: Epigenetics and nuclear signaling; Tags and; cell markers

Target Protein: CBX5 HP1A

Applications: IF, ICC, WB, IHC-p

Reactivity: Human,Mouse,Rat

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Chromobox protein homolog 5

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P45973; Mouse: Q61686

Synonyms: Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha

GeneID: Human: 23468

Research Use Only