Product Description

HPRT Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66751-50, MB66751-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: HPRT (hypoxanthine phosphoribosyltransferase 1), also known as HGPRT or HPRT1, is a 218 amino acid cytoplasmic protein that belongs to the purine/pyrimidine phosphoribosyltransferase family. Involved in purine metabolism, HPRT functions as a purine salvage enzyme that catalyzes the conversion of hypoxathine and guanine to their respective mononucleotides (inosine monophosphate and guanosine monophosphate, respectively). HPRT exists as a homotetramer that can bind two magnesium ions as cofactors. Defects in the gene encoding HPRT are the cause of gout and Lesch-Nyhan syndrome (LNS), both of which are characterized by a partial or complete lack of NPRT enzymatic activity. While a partial loss of HPRT enzymatic activity resμlts in a buildup of uric acid (gout), a total loss of enzymatic activity resμlts in hyperuricaemia, mental retardation, choreoathetosis and compμlsive selfmutilation, all of which are symptoms associated with LNS. The severity of these diseases suggests an essential role for HPRT in purine metabolism.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: HPRT, Hypoxanthine-guanine phosphoribosyltransferase, HGPRT, HGPRTase

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human HPRT. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Specificity: Recognizes endogenous levels of HPRT protein.

Molecular Weight: ~ 28 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P00492

Product: Mouse IgM. Supplied in crude ascites with 0.01% sodium azide.

Research Use Only