HSD11B1 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90663-50, BS90663-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P28845(Human) P50172(Mouse) P16232(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, IHC
All Applications: WB:1:500-1:2,000
IHC:1:50-1:200
Background: HSD11B1(Corticosteroid 11-beta-dehydrogenase isozyme 1) is also named as HSD11, HSD11L,11-DH and 11-beta-HSD1.It is a microsomal enzyme, which acts mainly as a NADP(H)- dependent reductase converting inactive cortisone (E) to active cortisol (F), thus regulating intracellular F access to glucocorticoid receptor. This enzyme is widely expressed not only in liver and adipose tissue, but also in adrenal, ovary and decidua.Western blot analysis in human liver, using a specific11-beta-HSD1 antibody, showed two bands at approximately 34 and 68 kDa confrming the dimeric nature of 11-beta-HSD1 in liver and In omental adipose tissue, an additional band of 50 kDa was strongly expressed.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: HSD11B1 polyclonal antibody detects endogenous levels of HSD11B1 protein.
Bioworld Molecular Weight: 32 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of HSD11B1 on mouse liver tissue lysate using anti-HSD11B1 antibody at 1/500 dilution., Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-HSD11B1 antibody. Counter stained with hematoxylin.
Alternative Name: 11-DH, 11-beta-HSD1, HSD11B1, HSD11, HSD11L, SDR26C1, 11 beta HSD 1, 11 beta HSD1, 11 beta hydroxysteroid dehydrogenase 1, 11 DH, 11-beta hydroxysteroid dehydrogenase, type 1, 11-beta-HSD1, 11-beta-hydroxysteroid dehydrogenase 1, 11-DH, 11DH, Corticosteroid 11 beta dehydrogenase isozyme 1, Corticosteroid 11-beta-dehydrogenase isozyme 1, CORTRD2, DHI1, HDL, HSD 11, HSD11, HSD11B, HSD11B1, HSD11L, Hydroxysteroid (11 beta) dehydrogenase, Hydroxysteroid (11 beta) dehydrogenase 1, MGC13539, SDR26C1, short chain dehydrogenase/reductase family 26C, member 1,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodified