Product Description

HSD17B1 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-65790-60, E-AB-65790-120, E-AB-65790-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: HSD17B1

Target Synonym: HSD17B1; 17-beta-HSD; 20-alpha-HSD; E2DH; EDH17B2; EDHB17; HSD17; SDR28C1

Research Areas: Cancer, Metabolism, Neuroscience, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: IHC, IF

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P14061

Background: Hydroxysteroid (17-beta) dehydrogenase 1 catalyzes the final step in the formation of estradiol and testosterone from estrone and androstenedione, respectively. Ovarian granulosa cells and breast tissue both express HSD17B1. Other tissues that express HSD17B1 include testis, placenta, uterus, prostate and adipose tissue. HSD17B1 functions as a homodimer and prefers NADP(H) over NAD(H) for oxidation and reduction. The gene encoding human HSD17B1 maps to chromosome 17q12-q21. The importance of HSD17B1 to estradiol production suggests the specific inhibition of HSD17B1 may aid in breast cancer therapy.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human HSD17B1 (NP_000404.2).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification Method: Affinity purification

Dilution: IHC 1:50-1:200 IF 1:50-1:200

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only