Product Description

HSD17B4 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60710-50, BS60710-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: 17β-HSD4 (17β-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal mμltifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme or 17-β Estradiol 17β-HSD4 (17β-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal mμltifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme or 17-β Estradiol dehydrogenase type IV. It belongs to the 17β-HSD family of proteins that regμlate the availability of steroids within various tissues throughout the body. 17β-HSD4 inactivates Estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol β-oxidation. It has a mμlti-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain. 17β-HSD4 is a target protein of chromeceptin and it is essential for the downstream activation of Stat6. 17β-HSD4-deficient patients exhibit Zellweger-like syndrome and die within the first year of life. They display neuronal migration defects, facial dysmorphisms, severe hypotonia and convμlsions in the neonatal period.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Peroxisomal mμltifunctional enzyme type 2, MFE-2, 17-beta-hydroxysteroid dehydrogenase 4, 17-beta-HSD 4, D-bifunctional protein, DBP, Mμltifunctional protein 2, MPF-2, HSD17B4, EDH17B4

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human HSD17B4

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: HSD17B4 polyclonal antibody detects endogenous levels of HSD17B4 protein.

Molecular Weight: ~ 79 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P51659

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only