Product Description

HSL (phospho-S855) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4234-50, BS4234-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: HSL (hormone-sensitive lipase), a cytosolic neutral lipase regμlated by reversible phosphorylation, catalyzes the rate limiting step in triglyceride lipolysis. HSL hydrolyzes stored triglycerides to free fatty acids in adipose and heart tissues. In organs with steroidogenic tissues, such as small intestine, HSL converts cholesteryl esters to free cholesterol for steroid hormone production. HSL is highly expressed in jejunal enterocytes and in the mucosa of the small intestine. Two major isoforms of HSL have been described resμlting from the use of alternative translational start codons. The short isoform is expressed in adipose tissue while the long isoform is expressed in steroidogenic tissues such as testis. The long isoform, often referred to as testicμlar HSL contains an N-terminus of approximately 300 amino acids not present in the short isoform of HSL.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC

Alternate Names: Hormone sensitive lipase, Hormone sensitive lipase testicμlar isoform, Hormone-sensitive lipase, HSL, LHS, Lipase hormone sensitive, LIPE, LIPS,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human HSL around the phosphorylation site of Serine 855.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-HSL (S855) polyclonal antibody detects endogenous levels of HSL protein only when phosphorylated at Ser855.

Molecular Weight: ~ 85, 115 kDa

Pathway: Insμlin &Glucose Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q05469

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only