Product Description

HSP47 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66959-50, MB66959-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Serpin peptidase inhibitor, clade H, member 1 (serpin H1), also known as heat shock protein 47 (HSP47), is a collagen specific molecμlar chaperone localized to the endoplasmic reticμlum, essential for collagen biosynthesis. Despite its lack of serine proteinase activity, serpin H1 is a member of the serpin superfamily . Genetic deletion of SERPINH1 or inhibition of its interaction with procollagen has been shown to greatly reduce procollagen secretion from fibroblasts, implicating serpin H1 as a potential target for therapeutic management of fibrosis . Moreover, altered serpin H1 expression has been seen in mμltiple cancer types, including colon carcinoma, head and neck squamous cell carcinoma, and liver hepatocellμlar carcinoma. Thus, serpin H1 may function as a potential prognostic biomarker for certain cancers .

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Mouse

Applications: WB, IHC

Alternate Names: CBP1, CBP2, HSP47, SERPINH2, Serpin H1, 47 kDa heat shock protein, Arsenic-transactivated protein 3, AsTP3, Cell proliferation-inducing gene 14 protein, Collagen-binding protein, Colligin, Rheumatoid arthritis-related antigen RA-A47

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human HSP47. The exact sequence is proprietary.

Dilution: WB (1/1000 - 1/2000), IHC (1/50 - 1/200)

Specificity: Recognizes endogenous levels of HSP47 protein.

Molecular Weight: ~ 46 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P50454

Product: Mouse IgG1. Supplied in crude ascites with 0.01% sodium azide.

Research Use Only