Product Description

HSP90 alpha Monoclonal Antibody

Catalogue Numbers: MB66828-50, MB66828-100

Sizes: 50µl, 100µl

Product: Mouse IgG1 lambda. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P07900

Host: Mouse

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB (1/1000 - 1/2000)

Background: The heat shock response was first described for Drosophila salivary gland cells and morphologically consists of a change in their polytene chromosome puffing patterns that involves de novo synthesis of a few proteins. Similar heat shock proteins were later discovered in bacterial chicken and mammalian cells, and have been subsequently studied in other organisms. A series of proteins including HSP 90, HSP 70, HSP 20-30 and ubiquitin are induced by insults such as temperature shock, chemicals and other environmental stres A major function of HSP 90 and other HSPs is to act as molecular chaperones. HSP 90 forms a complex with glucocorticoid receptor (GR), rendering the non ligandbound receptor transcriptionally inactive. HSP 90 binds the GR as a heterocomplex composed of either HSP 56 or Cyclophilin D, forming an aporeceptor comiplex. HSP 90 also exists as a dimer with other proteins such as p60/sti1 and p23, forming an apo-receptor complex with estrogen and androgen receptors.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of HSP90 alpha protein.

Extra Notes: Western blot analysis of HSP90 alpha expression in Hela (A), A431 (B), C6 (C), NIH3T3 (D) whole cell lysates.

Bioworld Molecular Weight: ~ 95 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: HSP90A; HSPC1; HSPCA; Heat shock protein HSP 90-alpha; Heat shock 86 kDa; HSP 86; HSP86; Lipopolysaccharide-associated protein 2; LAP-2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human HSP90 alpha. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified