Product Description

HURP Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA26134-50, RA26134-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: developmental stage:Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells., function:Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells., PTM:Ubiquitinated, leading to its degradation., similarity:Belongs to the SAPAP family., subcellular location:Localizes to the spindle poles in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells., subunit:Interacts with CDC2. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDC2/Cyclin B-phosphorylation dependent manner. Interacts with CDH1., tissue specificity:Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.,

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Alternate Names: DLGAP5, DLG7, KIAA0008, Disks large-associated protein 5, DAP-5, Discs large homolog 7, Disks large-associated protein DLG7, Hepatoma up-regulated protein, HURP

Clonality: Polyclonal

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Molecular Weight: 95

Protein Molecular Weight (kDa): 95

Storage: -20°C/1 year

Human Gene ID: 9787

Human SwissProt Number: Q15398

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only