Product Description

HUS1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA32697-50, RA32697-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: HUS1 checkpoint clamp component (HUS1) Homo sapiens The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight: 30

Protein Molecular Weight (kDa): 30

Storage: -20°C/1 year

Human Gene ID: 3364

Human SwissProt Number: O60921

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only