HUWE1 Polyclonal Antibody - BT-AP10232

HUWE1 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP10232-20, BT-AP10232-50, BT-AP10232-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation.

Research Areas: Cell biology

Target Protein: HUWE1

Applications: IHC-p, IF

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: E3 ubiquitin-protein ligase HUWE1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q7Z6Z7; Mouse: Q7TMY8; Rat: P51593

Synonyms: E3 ubiquitin-protein ligase HUWE1;EC 6.3.2.-;ARF-binding protein 1;ARF-BP1;HECT, UBA and WWE domain-containing protein 1;Homologous to E6AP carboxyl terminus homologous protein 9;HectH9;L

GeneID: Human: 10075

Research Use Only