Product Description

HUWE1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA32699-50, RA32699-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1) Homo sapiens This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation. [provided by RefSeq, Aug 2013],

Reactivity: Human, Mouse

Host: Rabbit

Applications: IHC-p, IF (paraffin section)

Clonality: Polyclonal

Dilution: IHC-p 1:50-300

Molecular Weight: 481

Protein Molecular Weight (kDa): 481

Storage: -20°C/1 year

Human Gene ID: 10075

Human SwissProt Number: Q7Z6Z7

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only