Product Description

HUWE1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA32699-50, RA32699-100

Citations, Manuals and MSDS Available upon request.

Background: HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1) Homo sapiens This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)) . This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation. [provided by RefSeq, Aug 2013],

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: IHC-p 1:50-300

Applications: IHC-p; IF (paraffin section)

Species Cross-Reactivity: Human; Mouse

GeneID (Human): 10075

Protein MW (KDa): 481

SWISS: Q7Z6Z7

Source: Rabbit

Research Use Only