hydrogen exchanger 3 Polyclonal Antibody Sizes: 50µl, 100µl Catalogue Numbers: BS65547-50, BS65547-100 Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Swiss-Prot: P48764 Host: Rabbit Reactivity: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Applications: WB All Applications: WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Background: NHE-3 are integral membrane proteins that are expressed in most mammalian tissues, where they regulate intracellular pH and cell volume. NHEs mediate the transport of hydrogen (H+) ions out of cells in exchange for extracellular sodium (Na+) ions. While NHE-1 is ubiquitously expressed, the NHE isoforms 2-8 have distinct tissue- and cell type-dependent expression and inhibitory characteristics. NHE-3 localizes to the apical membrane of renal proximal tubules where it is responsible for most of the sodium transport and fluid reabsorption. NHE-3 translocates to internal pools where it mediates natriuresis when blood pressure increases abruptly. NHE-3 is also expressed in the stomach and functions to protect the mucosa by secreting protons that diffuse into the mucous cells. Purification and Purity: affinity purified by Protein A Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity: hydrogen exchanger 3 polyclonal Antibody detects endogenous levels of hydrogen exchanger 3 protein. Bioworld Molecular Weight: ~80kDa Note: For research use only, not for use in diagnostic procedure. Extra Notes: Anti-hydrogen exchanger 3 at 1/1000 dilution Alternative Name: Na(+)/H(+) exchanger 3; NHE 3; NHE-3; NHE3; SL9A3_HUMAN; SLC9A 3; Sodium; Slc9a3; Sodium/hydrogen exchanger 3; Sodium/hydrogen exchanger, apical epithelial; Solute carrier family 9 (sodium/hydrogen exchanger), isoform 3; Solute carrier family 9 (sodium/hydrogen exchanger), member 3; Solute carrier family 9 member 3; MGC126718; MGC126720. Immunogen: KLH conjugated synthetic peptide derived from human hydrogen exchanger 3 :451-550/834 Conjugate: Unconjugated Modification: Unmodified