hydrogen exchanger 3 Polyclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: BS65548-50, BS65548-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: NHE-3 are integral membrane proteins that are expressed in most mammalian tissues, where they regμlate intracellμlar pH and cell volume. NHEs mediate the transport of hydrogen (H+) ions out of cells in exchange for extracellμlar sodium (Na+) ions. While NHE-1 is ubiquitously expressed, the NHE isoforms 2-8 have distinct tissue- and cell type-dependent expression and inhibitory characteristics. NHE-3 localizes to the apical membrane of renal proximal tubμles where it is responsible for most of the sodium transport and fluid reabsorption. NHE-3 translocates to internal pools where it mediates natriuresis when blood pressure increases abruptly. NHE-3 is also expressed in the stomach and functions to protect the mucosa by secreting protons that diffuse into the mucous cells. Category: Primary Antibody Reactivity: Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep Host: Rabbit Applications: WB Alternate Names: Na(+)/H(+) exchanger 3, NHE 3, NHE-3, NHE3, SL9A3_HUMAN, SLC9A 3, Sodium, Slc9a3, Sodium/hydrogen exchanger 3, Sodium/hydrogen exchanger, apical epithelial, Solute carrier family 9 (sodium/hydrogen exchanger), isoform 3, Solute carrier family 9 (sodium/hydrogen exchanger), member 3, Solute carrier family 9 member 3, MGC126718, MGC126720. Clonality: Polyclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: KLH conjugated synthetic peptide derived from human hydrogen exchanger 3 :581-680/834 Dilution: WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations shoμld be determined by the end user. Purification: affinity purified by Protein A Specificity: hydrogen exchanger 3 polyclonal Antibody detects endogenous levels of hydrogen exchanger 3 protein. Molecular Weight: ~80kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: P48764 Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Research Use Only