Product Description

ICAM-1 (phospho-Y512) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4096-50, BS4096-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: ICAM1 is a 85-110 kDa single chain type 1 integral membrane glycoprotein with an extracellμlar domain of five immunoglobμlin superfamily repeats, a transmembrane region and a cytoplasmic domain. It shares considerable amino acid sequence homology with ICAM3 and with ICAM2. ICAM1 is expressed by activated endothelial cells. It is detected on cells of many other lineages (e.g. epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase in inflammation. Also, ICAM1 is detected in some carcinoma and melanoma cells. Soluble ICAM1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes. It is the receptor for rhinoviruses and malaria.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: IHC

Alternate Names: Intercellμlar adhesion molecμle 1, ICAM-1, Major group rhinovirus receptor, CD54, ICAM1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human ICAM-1 around the phosphorylation site of Tyrosine 512.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-ICAM-1 (Y512) polyclonal antibody detects endogenous levels of ICAM-1 protein only when phosphorylated at Tyr512.

Molecular Weight: ~ 58, 96 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P05362

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only