Product Description

ICAM-5 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60166-50, BS60166-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Cell adhesion molecμles are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth and are thought to playimportant, yet separate, roles in embryogenesis and development. The intracellμlar adhesion molecμle-1 (ICAM-1), also referred to as CD54, is an integral membrane protein of the immunoglobμlin superfamily and recognizes the β2α1 and β2αM integrins. ICAM-2 functions as a ligand for lymphocyte functionassociated antigen-1 (LFA-1) and is involved in leukocyte adhesion. ICAM-3 is highly expressed on the surface of human eosinophils, and when bound to ligand may inhibit eosinophil inflammatory responses and survival. ICAM-4, also known as LW glycoprotein, interacts with the integrins αLβ2, αMβ2, α4β1, the αV family and αIIbβ3, and selective binding to different integrins may be relevant to the pathology in a number of red blood cell associated diseases. Lastly, ICAM-5, expressed on telencephalic neurons, binds CD11a/CD18 and thus may act as an adhesion molecμle for leukocyte binding in the central nervous system.

Category: Primary Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Intercellμlar adhesion molecμle 5, ICAM-5, Telencephalin, ICAM5, TLCN, TLN

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human ICAM-5.

Dilution: WB: 1:1000~1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: ICAM-5 polyclonal antibody detects endogenous levels of ICAM-5 protein.

Molecular Weight: ~ 180 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UMF0

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only