Product Description

ICOSL Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS8696-50, BS8696-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Inducible co-stimμlator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimμlatory molecμles related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellμlar IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimμlatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimμlatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimμlating T cell immune responses. Deficiency in either pathway resμlts in defective T cell activation, cytokine production and germinal center formation.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: ICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human ICOSL(NP_056074.1).

Dilution: WB, 1:500 - 1:2000 IHC, 1:50 - 1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Polyclonal Antibodies

Molecular Weight: 60KDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O75144

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only