IDE Monoclonal Antibody (3H4) - RA10628

IDE Monoclonal Antibody (3H4) Size: 50μL, 100μL Catalogue Numbers: RA10628-50, RA10628-100 Citations, Manuals and MSDS Available upon request. Background: insulin degrading enzyme (IDE) Homo sapiens This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been describe Condition: PBS, pH 7.4, containing 0.5% BSA, 0.02% sodium azide as Preservative and 50% Glycerol. Storage Instructions: -20°C/1 year Applications: WB; IHC-p; IF/ICC; Species Cross-Reactivity: Human GeneID (Human): 3416 Protein MW (KDa): 118 SWISS: P14735 Source: Mouse Research Use Only