Product Description

IDE Monoclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-22041-60, E-AB-22041-120, E-AB-22041-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: IDE

Target Synonym: Abeta-degrading protease; FLJ35968; Ide; IDE; Insulin protease; Insulin-degrading enzyme; Insulinase; Insulysin; OTTHUMP00000020097

Research Areas: Cancer, Cell Biology, Cardiovascular, Metabolism, Neuroscience, Signal Transduction

Conjugation: Unconjugated

Host: Mouse

Species Reactivity: Human

Application: WB, IHC-p, IF

Isotype: IgG

Clonality: Monoclonal

Clone No.: Clone:1H4

UNIProt ID: P14735

Background: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.

Concentration: 1 mg/mL

Immunogen: Synthetic Peptide

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Purification Method: Protein A purification

Dilution: WB 1:500-1:2000, IHC 1:50-300, IF 1:100-1:300

Observed MW: 118kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only