Product Description

IDE Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS49521-50, BS49521-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a zinc metallopeptidase that degrades intracellμlar insμlin, and thereby terminates insμlins activity, as well as participating in intercellμlar peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insμlin resμlts in insμlin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellμlar space, cell membrane, peroxisome, and mitochondrion. Alternative splicing resμlts in mμltiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ICC/IF, FC

Alternate Names: INSμlYSIN

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide of human Insμlin degrading enzyme/IDE

Dilution: WB: 1:2000-1:10000 ICC/IF: 1:20 FC: 1:20

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 118 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P14735

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only