IDH2 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90684-50, BS90684-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P48735(Human) P54071(Mouse) P56574(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, IHC FC
All Applications: WB:1:500-1:2,000
IHC:1:50-1:200
FC:1:50-1:100
Background: IDH2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial), also designated NADP+-specific ICDH; isocitrate dehydrogenase, mitochondrial; and oxalosuccinate decarboxylase, is a 452 amino acid enzyme encoded by the human gene IDH2. IDH2 belongs to the isocitrate and isopropylmalate dehydrogenases family and contains two nucleotide binding regions. IDH2 is involved in the reduction of NADP+ to NADPH and maintains the supply of glutathione (GSH) in mitochondria. It is believed to play a role in intermediary metabolism and energy production. IDH2 also tightly associates with the pyruvate dehydrogenase complex. IDH2 is found in the mitochondrion as a homodimer and can bind one magnesium or manganese ion per subunit.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: IDH2 polyclonal antibody detects endogenous levels of IDH2 protein.
Bioworld Molecular Weight: 45 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of IDH2 on different cell lysate using anti-IDH2 antibody at 1/1,000 dilution.
Positive control: Line 1: Mouse heart Line 2: Rat heart Line 3: 293T, Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-IDH2 antibody. Counter stained with hematoxylin.
Alternative Name: IDH, IDH2, D2HGA2, ICD-M, IDH, IDH2, IDHM, IDHP, IDP, IDPM, Isocitrate dehydrogenase [NADP], mitochondrial, Isocitrate dehydrogenase 2 (NADP+), mitochondrial, mNADP-IDH, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified