Product Description

IDHP Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA26153-50, RA26153-100

Citations, Manuals and MSDS Available upon request.

Background: isocitrate dehydrogenase (NADP (+)) 2, mitochondrial (IDH2) Homo sapiens Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD (+) as the electron acceptor and the other NADP (+) . Five isocitrate dehydrogenases have been reported: three NAD (+) -dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP (+) -dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP (+) -dependent isozyme is a homodimer. The protein encoded by this gene is the NADP (+) -dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by Ref

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: IHC-p 1:50-200, WB 1:500-2000

Alternative Names: Isocitrate dehydrogenase [NADP], mitochondrial (IDH;EC 1.1.1.42;ICD-M;IDP;NADP (+) -specific ICDH;Oxalosuccinate decarboxylase)

Applications: IHC-p; IF (paraffin section) ; WB

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 3418

Protein MW (KDa): 48

SWISS: P48735

Source: Rabbit

Research Use Only