IF5A1 rabbit pAb - ES11898

IF5A1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES11898-50, ES11898-100

Citations, Manuals and MSDS Available upon request.

Background: function:The precise role of eIF-5A in protein biosynthesis is not known but it functions by promoting the formation of the first peptide bond., PTM:eIF-5A seems to be the only eukaryotic protein to have an hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine)., similarity:Belongs to the eIF-5A family., subunit:Found in a complex with Ran and XPO4. The hypusine modification increases the interaction with XPO4., tissue specificity:Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).,

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from part region of human protein

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 16kD

Human Gene ID: 1984

Human SWISS Prot NO: P63241

Subcellular Location: Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions (PubMed:19379712, PubMed:27306458). Nuclear export of hypusinated protein is mediated by XPO4 (PubMed:10944119, PubMed:27306458).

Research Use Only