IF6 Polyclonal Antibody - BT-AP08661

IF6 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP08661-20, BT-AP08661-50, BT-AP08661-100

Citations, Manuals and MSDS Available upon request.

Background: Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4)| a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein| which is insoluble and found both in the nucleus and in the cytoplasm| can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene.

Research Areas: Epigenetics and nuclear signaling; Neuroscience

Target Protein: EIF6

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Eukaryotic translation initiation factor 6

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P56537; Mouse: O55135; Rat: Q3KRD8

Synonyms: Eukaryotic translation initiation factor 6 (eIF-6;B(2)GCN homolog;B4 integrin interactor;CAB;p27(BBP))

GeneID: Human: 3692

Research Use Only