Product Description

IFIT3 Mouse Monoclonal Antibody

Sizes: 25μl, 100μl

Catalogue Numbers: MB4022-25, MB4022-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: IFIT3 (Interferon-induced protein with tetratricopeptide repeats 3, Retinoic acid-induced gene G protein (RIG-G)) is part of the IFIT family of interferon-stimμlating genes known for their antiviral properties (1, 2). IFIT3 is widely expressed in T cells, B cells, plasmacytoid and myeloid dendritic cells, neurons, and kidney cells (3, 4). In response to RNA viral infection, IFIT3 regμlates IRF3 activation through interaction with TBK1 and MAVS on the mitochondrion (5). IFIT3 also interacts with IFIT1, leading to inhibitory activity against viral RNA lacking the 2′-O-methylation in the cap structure (6).

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Mouse

Applications: FC, IF, WB

Alternate Names: Gem-associated protein 2, Gemin-2, Component of gems 2, Survival of motor neuron protein-interacting protein 1 (SMN-interacting protein 1), GEMIN2, SIP1

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Fμll length human recombinant protein of human IFIT3 (NP_001540) produced in HEK293T cell.

Dilution: WB 1:2000, IF 1:100, Flow 1:100

Purification: The antibody was affinity-purified from mouse ascites fluids or tissue cμlture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IgG1

Molecular Weight: ~60-65 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O14879

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only