Product Description

IFITM3 Monoclonal Antibody

Catalogue Numbers: MB67067-50, MB67067-100

Sizes: 50µl, 100µl

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: Q01628

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/1000 - 1/2000)

Background: Interferon-induced transmembrane protein (IFITM) family members are composed of short amino- and carboxy-termini, two transmembrane domains, and a cytoplasmic domain. There are four family members in humans: IFITM1, IFITM2, IFITM3, and IFITM5. Mice have two additional family members, IFITM6 and IFITM7. Basal expression of IFITM proteins is observed in some cells and expression can also be induced by type I and type II interferons. The primary function of IFITM family proteins appears to be viral restriction, as IFITM proteins inhibit cytosolic entry of viruses by preventing fusion of viral and host membranes. The mechanism by which IFITM proteins inhibit fusion is unclear. Although IFITM proteins are present on both the plasma membrane and intracellular membranes, they most effectively restrict viral fusion in late endosomes and lysosomes. In addition, different family members exhibit specific viral preferences. For example, IFITM3 is most effective at restricting influenza A infection, while IFITM1 is more successful in controlling filoviruses and SARS.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of IFITM3 protein.

Extra Notes: Western blot analysis of IFITM3 expression in NCIH460 (A), HepG2 (B) whole cell lysates.

Bioworld Molecular Weight: ~ 17 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Interferon-induced transmembrane protein 3; Dispanin subfamily A member 2b; DSPA2b; Interferon-inducible protein 1-8U

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IFITM3. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified