Product Description

IFITM3 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67067-50, MB67067-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Interferon-induced transmembrane protein (IFITM) family members are composed of short amino- and carboxy-termini, two transmembrane domains, and a cytoplasmic domain. There are four family members in humans: IFITM1, IFITM2, IFITM3, and IFITM5. Mice have two additional family members, IFITM6 and IFITM7. Basal expression of IFITM proteins is observed in some cells and expression can also be induced by type I and type II interferons. The primary function of IFITM family proteins appears to be viral restriction, as IFITM proteins inhibit cytosolic entry of viruses by preventing fusion of viral and host membranes. The mechanism by which IFITM proteins inhibit fusion is unclear. Although IFITM proteins are present on both the plasma membrane and intracellμlar membranes, they most effectively restrict viral fusion in late endosomes and lysosomes. In addition, different family members exhibit specific viral preferences. For example, IFITM3 is most effective at restricting influenza A infection, while IFITM1 is more successfμl in controlling filoviruses and SARS.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: Interferon-induced transmembrane protein 3, Dispanin subfamily A member 2b, DSPA2b, Interferon-inducible protein 1-8U

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IFITM3. The exact sequence is proprietary.

Dilution: WB (1/1000 - 1/2000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of IFITM3 protein.

Molecular Weight: ~ 17 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q01628

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only