Product Description

IFITM3 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS5762-50, BS5762-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: IFITM3 (interferon induced transmembrane protein 3), also known as 1-8U or IP15, is a mμlti-pass membrane protein that belongs to the IFITM (interferon inducible transmembrane) family of proteins. IFITM proteins are induced by type I and type II interferons and contain mμltiple interferon (IFN)-stimμlated response elements (ISREs) in their promoter regions. IFITM proteins play important roles in many cellμlar processes and their expression requires the presence of the chromatin remodeling SWI/SNF-like BAF complexes. Cellμlar processes involving IFITM proteins include cellμlar anti-proliferative activities and homotypic cell adhesion functions of interferons. In addition, IFITM genes are often upregμlated in various cancer cells, suggesting a possible role in carcinogenesis. Localizing to the membrane, IFITM3 is a 133 amino acid protein that is induced by IFN-α and IFN-γ. IFITM3 expression can be regμlated by TEF-1, Brg-1 and Sp1.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ICC

Alternate Names: Interferon-induced transmembrane protein 3, Dispanin subfamily A member 2b, DSPA2b, Interferon-inducible protein 1-8U, Fragilis

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 9-54 of Human IFITM3.

Dilution: WB: 1:500~1:1000
ICC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IFITM3 polyclonal antibody detects endogenous levels of IFITM3 protein.

Molecular Weight: ~ 15 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q01628

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only