IFNAR1 Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB9283-50, MB9283-100
Product: Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P17181(Human) P33896(Mouse)
Host: Mouse
Reactivity: Human, Mouse
Applications: WB, IHC ICC
All Applications: WB:1:500
ICC:1:50-1:200
IHC:1:50-1:200
Background: Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.
Purification and Purity: ProG affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: IFNAR1 monoclonal antibody detects endogenous levels of IFNAR1 protein.
Bioworld Molecular Weight: 56 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of IFNAR1 on different lysates using anti- IFNAR1 antibody at 1/500 dilution.
Positive control:
Lane 1: K562
Lane 1: A431
Lane 1: Siha
Lane 1: Mouse brain tissue, ICC staining IFNAR1(red) in NCCIT cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: IFN-R-1, IFN-alpha/beta receptor 1, CRF2-1, IFNAR1, IFNAR, Alpha type antiviral protein, Antiviral protein, alpha-type, Antiviral protein, beta-type, AVP, Beta type antiviral protein, CRF2-1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, IFN alpha REC, IFN alpha receptor, IFN alpha/beta Receptor alpha, IFN beta receptor, IFN Interferon-beta receptor, IFN-alpha/beta receptor 1, IFN-R-1, IFNAR, Ifnar1, IFNBR, IFRC, INAR1, Interferon (alpha beta and omega) receptor 1, interferon alpha and beta receptor subunit 1, Interferon alpha/beta receptor 1, Interferon alpha/beta receptor alpha chain, Interferon beta receptor 1, interferon receptor 1, Interferon-alpha receptor, Type I interferon receptor 1,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodified