IgA Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90687-50, BS90687-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P01876(Human) P01877(Human)
Host: Rabbit
Reactivity: Human
Applications: WB, ICC/IF, IHC, IP,
All Applications: WB:1:1,000
ICC:1:50-1:200
IHC:1:50-1:200
IP:1:50-1:100
Background: Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through interchain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins. The IgA heavy chain is an α-chain, and the light chains are either κ- or λ- chains. IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: IgA polyclonal antibody detects endogenous levels of IgA protein.
Bioworld Molecular Weight: 60 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of IgA on human plasma lysates using anti-IgA antibody at 1/1,000 dilution., ICC staining IgA in HepG2 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: IGHA1, IGHA2, Hepatocellular carcinoma-associated protein TB6, Ig alpha 1 chain C region, Ig alpha 2 chain C region, IGHA, IGHA1, IGHA2, Immunoglobulin heavy constant alpha 1, Immunoglobulin heavy constant alpha 2 A2m marker, Immunoglobulin heavy constant alpha 2, PIgR, Poly-Ig receptor, polymeric immunoglobulin receptor, polymeric immunoglobulin receptor Secretory component,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified