IgA (Y276) Polyclonal Antibody-BS3526

IgA (Y276) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS3526-50, BS3526-100

Sizes: 50µl, 100µl

Swiss-Prot: P01876/P01877

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, IHC

Background: Human IgA (immunoglobulin A) is a glycosylated protein of 160 kDa and is produced as a monomer or as a J chain linked dimer. Monomeric IgA constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defence by neutralising infectious agents at mucosal surfaces. The production is usually local and antigen specific IgA producing B cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IgA (Y276) polyclonal antibody detects endogenous levels of IgA protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of IGHA1/IGHA2 pAb at 1:1000 dilution
Lane 1: AML-12 whole cell lysate (40ug)
Lane 2: SGC7901 whole cell lysate (40ug)
Lane 3: A549 whole cell lysate (40ug)
Lane 4: HepG2 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of IgA (Y276) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 38 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Ig alpha-1 chain C region; IGHA1; Ig alpha-2 chain C region; IGHA2

Immunogen: Synthetic peptide, corresponding to amino acids 241-290 of Human IgA.

Conjugate: Unconjugated

Modification: Unmodified