Product Description

IGF-1R (G1155) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1182-50, BS1182-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Insμlin-like growth factor-I receptor (IGF-IR) is an RTK that stimμlates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimμlate the growth of some types of cancer. The IGF-IR cognate ligand insμlin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modμlar phosphotyrosine binding (PTB) domains of insμlin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Insμlin-like growth factor 1 receptor, Insμlin-like growth factor I receptor, IGF-I receptor, CD221, Insμlin-like growth factor 1 receptor alpha chain, Insμlin-like growth factor 1 receptor beta chain, IGF1R

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 1121-1170 of Human IGF-1R.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IGF-1R (G1155) polyclonal antibody detects endogenous levels of IGF-1R protein. This antibody may cross-reacts with insμlin receptor protein.

Molecular Weight: ~ 95, 155 kDa

Pathway: Tumor Angiogenesis, Insμlin &Glucose Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P08069/P06213

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only