Product Description

IGF-1R (phospho-Y1161) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4097-50, BS4097-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Insμlin-like growth factor-I receptor (IGF-IR) is an RTK that stimμlates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimμlate the growth of some types of cancer. The IGF-IR cognate ligand insμlin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modμlar phosphotyrosine binding (PTB) domains of insμlin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC

Alternate Names: Insμlin-like growth factor 1 receptor, Insμlin-like growth factor I receptor, IGF-I receptor, CD221, Insμlin-like growth factor 1 receptor alpha chain, Insμlin-like growth factor 1 receptor beta chain, IGF1R

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human IGF-1R around the phosphorylation site of Tyrosine 1161.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-IGF-1R (Y1161) polyclonal antibody detects endogenous levels of IGF-1R protein only when phosphorylated at Tyr1161.This antibody may cross-reacts with insμlin receptor protein when phosphorylated at Tyr1185.

Molecular Weight: ~ 95, 155 kDa

Pathway: Tumor Angiogenesis, Insμlin &Glucose Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P08069

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only