IGF-IR (phospho Tyr1161) rabbit pAb - ES1515

IGF-IR (phospho Tyr1161) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES1515-50, ES1515-100

Citations, Manuals and MSDS Available upon request.

Background: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],

Alternate Name: IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221; INSR; Insulin receptor; IR; CD antigen CD220

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized phospho-peptide around the phosphorylation site of human IGF-IR (phospho Tyr1161)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): pro: 155kD, recetor beta: 95kD

Human Gene ID: 3480

Human SWISS Prot NO: P08069/P06213

Subcellular Location: Cell membrane; Single-pass type I membrane protein.

Research Use Only