Product Description

IGF2BP2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS67673-50, BS67673-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modμlates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation . Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability . Binds to the 5'-UTR of the insμlin-like growth factor 2 (IGF2) mRNAs . Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD .

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB

Alternate Names: IMP2, VICKZ2, Insμlin-like growth factor 2 mRNA-binding protein 2, IGF2 mRNA-binding protein 2, IMP-2, Hepatocellμlar carcinoma autoantigen p62, IGF-II mRNA-binding protein 2, VICKZ family member 2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IGF2BP2. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of IGF2BP2 protein.

Molecular Weight: ~ 62 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9Y6M1

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only