IGF2BP2 Polyclonal Antibody-BS67673

IGF2BP2 Polyclonal Antibody

Catalogue Numbers: BS67673-50, BS67673-100

Sizes: 50µl, 100µl

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: Q9Y6M1

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation . Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability . Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs . Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD .

Purification and Purity: The antibody was purified by immunogen affinity chromatography.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of IGF2BP2 protein.

Extra Notes: Western blot analysis of IGF2BP2 expression in HEK293T (A), H1792 (B), K562 (C) whole cell lysates.

Bioworld Molecular Weight: ~ 75 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: IMP2; VICKZ2; Insulin-like growth factor 2 mRNA-binding protein 2; IGF2 mRNA-binding protein 2; IMP-2; Hepatocellular carcinoma autoantigen p62; IGF-II mRNA-binding protein 2; VICKZ family member 2

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IGF2BP2. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified