IGF2R Polyclonal Antibody - E-AB-68294

IGF2R Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-68294-60, E-AB-68294-120, E-AB-68294-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: IGF2R

Target Synonym: IGF2R; CD222; CI-M6PR; CIMPR; M6P-R; M6P/IGF2R; MPR 300; MPR1; MPR300; MPRI

Research Areas: Cancer, Immunology, Signal transduction, Tags and Cell markers

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: WB, IF

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P11717

Background: This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611).

Concentration: 1 mg/mL

Immunogen: Recombinant fusion protein of human IGF2R

Buffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000, IF 1:50-1:200

Calculated MW: 274kDa

Observed MW: 274KDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only