IgG1 rabbit pAb - ES5860

IgG1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES5860-50, ES5860-100

Citations, Manuals and MSDS Available upon request.

Background: disease:Chromosomal aberrations involving IGHG1 may be a cause of multiple myeloma [MIM:254500]. Translocation t (11; 14) (q13; q32) with CCND1; translocation t (4; 14) (p16.3; q32.3) with FGFR3; translocation t (6; 14) (p25; q32) with IRF4., miscellaneous:Disease protein OMM may represent an allelic form or another gamma chain subclass., miscellaneous:Disease protein WIS is lacking most of the V region and all of the CH1 region., miscellaneous:Disease protein ZUC lack most of the V region, all of the CH1 region, and part of the hinge compared with normal gamma-3 heavy chains., miscellaneous:EU also differs in the amidation states of residues 155, 166, 177, 195, 198, 269, and 272 and in the order of residues 268-272., miscellaneous:KOL also differs in the amidation states of residues 198, 267 and 272., miscellaneous:Nie also differs in the amidation states of 35, 116, 198, 269 and 272., miscellaneous:Nie has the G1M (17) allotypic marker, 97-K, and the G1M (1) markers, 239-D and 241-L. KOL and EU sequences have the G1M (3) marker and the G1M (non-1) markers., miscellaneous:The hinge region in gamma-3 chains is about four times as long as in other gamma chains and contains three identical 15-residue segments preceded by a similar 17-residue segment (12-28)., online information:IGHM mutation db, polymorphism:All 4 combinations of the S/G and V/G polymorphisms at positions 191 and 216 have been observed in human mu chains., subcellular location:During differentiation, B-lymphocytes switch from expression of membrane-bound IgM to secretion of IgM., subunit:Dimer linked by 12 disulfide bonds; it has an extra interchain disulfide bond at position 7 in addition to the 11 normally present in the hinge region.,

Alternate Name: IGHG1; Ig gamma-1 chain C region

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Reactivity: Human; Rat; Mouse;

Immunogen: The antiserum was produced against synthesized peptide derived from human IgG1. AA range:196-245

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 41kD

Human Gene ID: 3500

Human SWISS Prot NO: P01857

Subcellular Location: Secreted. Cell membrane.

Research Use Only