IGHD Monoclonal Antibody-MB66772

IGHD Monoclonal Antibody

Catalogue Numbers: MB66772-50, MB66772-100

Sizes: 50µl, 100µl

Product: Mouse IgM. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P01880

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/100 - 1/500)

Background: IgD chain C (Ig d chain C region) is an allelic product of the human IGHD gene. The two known IGHD alleles, IGHD*01 and IGHD*02, respectively produce isoforms 1, a secreted protein, and 2, a single-pass type I membrane protein. A member of the adaptive immune system, IgD antibodies are monomers expressed by activated B cells. Containing three Ig-like (immunoglobulin-like) domains, IgD chain C is located on chromosome 14 within the human heavy chain locus, lying on the 3' side of the IgM chain C region from the V-D-J cassette. Polyadenylation at certain sites along the heavy chain locus likely effects the mechanism that determines the alternative splicing event which results in the expression of either IgD chain C or IgM chain C. Some studies have suggested that antigenic coactivation of IgD+ B cells can have a negative influence on bone resorption during infectious events.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of IGHD protein.

Extra Notes: Western blot analysis of IGHD expression in CEM (A) whole cell lysates.

Bioworld Molecular Weight: ~ 57 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Ig delta chain C region

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IGHD. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified