IgM Chain C rabbit pAb - ES8492

IgM Chain C rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8492-50, ES8492-100

Citations, Manuals and MSDS Available upon request.

Background: Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which d

Alternate Name: Ig mu chain C region

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from IgM Chain C at AA range: 391-440

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 50kD

Human SWISS Prot NO: P01871

Subcellular Location: [Isoform 1]: Secreted. During differentiation, B-lymphocytes switch from expression of membrane-bound IgM to secretion of IgM.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.

Research Use Only