Ikaros (C-term) Mouse Monoclonal Antibody - RA10541

Ikaros (C-term) Mouse Monoclonal Antibody

Size: 50μL, 100μL

Catalogue Numbers: RA10541-50, RA10541-100

Citations, Manuals and MSDS Available upon request.

Background: IKAROS family zinc finger 1 (IKZF1) Homo sapiens This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Applications: WB; IP

Species Cross-Reactivity: Human

GeneID (Human): 10320

Protein MW (KDa): 58

SWISS: Q13422

Source: Mouse

Research Use Only